Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
9
Eicosapentaenoic acid benefits cholesterol
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Read More
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
Most Useful Reviews
4
Omega-3 benefits
1 people found this helpful
Evidence shows omega-3 acids are crucial during pregnancy for the child’s brain and nervous system development. Fish oil assists pregnant women by improving immunity, promoting cardiovascular health, and reducing bad cholesterol. It also aids fetal growth and can decrease allergies, helping both mother and child.
Read More
9
High cholesterol relief
15 people found this helpful
I found this product to be of very high quality. Living in Moscow, I struggled to find an omega supplement for pregnant women to address my high cholesterol as prescribed by my endocrinologist. This omega has a pleasant smell of fish. It doesn’t disgust me and feels just like taking a regular vitamin. I recommend it without hesitation!
Read More
9
High DHA importance
8 people found this helpful
My wife, prescribed high DHA for her pregnancy after four years of trying to conceive, takes it daily. We chose this supplement carefully to avoid heavy metals, despite the higher cost. DHA is vital for the baby's brain and bodily development, and we believe it is a worthwhile investment in our future.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.7
- All Researches
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
Read More
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
9
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Read More
9
We explored the effects of eicosapentaenoic acid (EPA) from Antarctic krill oil (ESKO) on cholesterol levels and obesity-related conditions. Through a carefully designed study involving mice on a high-fat diet, we wanted to see if ESKO could improve cholesterol metabolism and reduce fat accumulation.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
We found that diets high in fat significantly increased oxidative stress and indicators associated with obesity. However, supplementation with ESKO appeared to counteract these negative effects, helping to reduce fat buildup and improve cholesterol levels.
Specifically, ESKO improved important metabolic pathways and reduced the activity of certain proteins that typically promote high cholesterol. This suggests that eicosapentaenoic acid from krill oil could play a crucial role in tackling high cholesterol and obesity-related disorders.
Read More
9
Eicosapentaenoic acid reduces cholesterol inflammation
We explored how eicosapentaenoic acid (EPA) affects cholesterol levels and the risk of type 2 diabetes (T2D). Our study focused on individuals with high levels of atherogenic lipoproteins, specifically apoB, which are known to predict higher diabetes risk. Over a twelve-week period, participants received daily doses of EPA and docosahexaenoic acid (DHA) to see how these omega-3 fatty acids influenced the secretion of interleukin-1 beta (IL-1β) from human white adipose tissue (WAT).
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
Remarkably, our results showed that EPA and DHA treatment effectively normalized the IL-1β secretion levels in participants who initially had high apoB. After the intervention, LDL cholesterol no longer triggered IL-1β secretion, and the omega-3 supplementation also improved overall β-cell function and fat metabolism. This means that not only did EPA and DHA reduce inflammation linked to high cholesterol, but they also appeared to enhance metabolic health.
Additionally, we found that the supplementation reduced the association between WAT inflammasome activity and various cardiometabolic risk factors, such as increased body fat. In laboratory tests, EPA and DHA inhibited WAT IL-1β secretion in a dose-dependent manner. These findings suggest that incorporating EPA and DHA into our diets may help prevent diabetes and its related health issues in individuals with high apoB levels.
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User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
4
Omega-3 benefits
1 people found this helpful
Evidence shows omega-3 acids are crucial during pregnancy for the child’s brain and nervous system development. Fish oil assists pregnant women by improving immunity, promoting cardiovascular health, and reducing bad cholesterol. It also aids fetal growth and can decrease allergies, helping both mother and child.
Read More
9
High cholesterol relief
15 people found this helpful
I found this product to be of very high quality. Living in Moscow, I struggled to find an omega supplement for pregnant women to address my high cholesterol as prescribed by my endocrinologist. This omega has a pleasant smell of fish. It doesn’t disgust me and feels just like taking a regular vitamin. I recommend it without hesitation!
Read More
9
High DHA importance
8 people found this helpful
My wife, prescribed high DHA for her pregnancy after four years of trying to conceive, takes it daily. We chose this supplement carefully to avoid heavy metals, despite the higher cost. DHA is vital for the baby's brain and bodily development, and we believe it is a worthwhile investment in our future.
Read More
7.5
Improved cholesterol levels
10 people found this helpful
I’m grateful to have found DHA for my wife. It’s easy on her stomach and lacks the fish oil taste. Since she began this supplement, I’ve noticed a positive change in her mood. For the first time, her good cholesterol has increased, which we attribute to the DHA, making it definitely worth the investment.
Read More
Frequently Asked Questions
7.5
Improved cholesterol levels
10 people found this helpful
I’m grateful to have found DHA for my wife. It’s easy on her stomach and lacks the fish oil taste. Since she began this supplement, I’ve noticed a positive change in her mood. For the first time, her good cholesterol has increased, which we attribute to the DHA, making it definitely worth the investment.
4
Omega-3 benefits
1 people found this helpful
Evidence shows omega-3 acids are crucial during pregnancy for the child’s brain and nervous system development. Fish oil assists pregnant women by improving immunity, promoting cardiovascular health, and reducing bad cholesterol. It also aids fetal growth and can decrease allergies, helping both mother and child.
9
High DHA importance
8 people found this helpful
My wife, prescribed high DHA for her pregnancy after four years of trying to conceive, takes it daily. We chose this supplement carefully to avoid heavy metals, despite the higher cost. DHA is vital for the baby's brain and bodily development, and we believe it is a worthwhile investment in our future.
9
High cholesterol relief
15 people found this helpful
I found this product to be of very high quality. Living in Moscow, I struggled to find an omega supplement for pregnant women to address my high cholesterol as prescribed by my endocrinologist. This omega has a pleasant smell of fish. It doesn’t disgust me and feels just like taking a regular vitamin. I recommend it without hesitation!
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
We conducted a study to investigate the impact of orange juice enriched with vitamin D3 and probiotics on various health markers, including cholesterol levels, in individuals with overweight or obesity following a Westernized diet. Fifty-three participants were divided into two groups for eight weeks—one group consumed the enriched orange juice while the other drank regular orange juice, creating a controlled environment for comparison.
After the study period, we noticed some promising changes in the group that consumed the enriched orange juice. While there were significant improvements in weight loss, reduced insulin levels, and better lipid profiles overall, it’s essential to note that we did not observe a clear reduction in high cholesterol levels from vitamin D3 alone. The enriched juice did help lower total cholesterol by a small margin, but not enough to draw definitive conclusions about the effectiveness of vitamin D3 on high cholesterol specifically.
In summary, while we saw various health benefits from the intervention, the specific role of vitamin D3 in lowering cholesterol remains unclear due to the combination of factors involved and the moderate changes we observed. This research highlights the need for further studies to isolate the effects of vitamin D3 more clearly.
After the study period, we noticed some promising changes in the group that consumed the enriched orange juice. While there were significant improvements in weight loss, reduced insulin levels, and better lipid profiles overall, it’s essential to note that we did not observe a clear reduction in high cholesterol levels from vitamin D3 alone. The enriched juice did help lower total cholesterol by a small margin, but not enough to draw definitive conclusions about the effectiveness of vitamin D3 on high cholesterol specifically.
In summary, while we saw various health benefits from the intervention, the specific role of vitamin D3 in lowering cholesterol remains unclear due to the combination of factors involved and the moderate changes we observed. This research highlights the need for further studies to isolate the effects of vitamin D3 more clearly.
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
References
- Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226
- Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. doi:10.1615/CritRevImmunol.2024052129
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
- Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
- Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. doi:10.1007/s11033-024-09408-6
- Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. doi:10.1080/10790268.2023.2257850
- Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. doi:10.1139/cjpp-2022-0359
- Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. doi:10.3390/nu15071645
- Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. doi:10.3389/fphar.2023.1135516
- Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. doi:10.3390/life13020581
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
- Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. doi:10.1016/j.foodres.2025.115733
- Yoshikiyo K, Shimizu H, Nagato EG, Ishizuka S, Yamamoto T. Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. Molecules. 2025;30. doi:10.3390/molecules30020281
- Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
- Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Bashir B, Schofield J, Downie P, France M, Ashcroft DM, et al. Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape-focus on hypertriglyceridaemia. Front Cardiovasc Med. 2024;11:1389106. doi:10.3389/fcvm.2024.1389106
- Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. doi:10.3389/fneph.2024.1365809
- Omari M, Alkhalil M. Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies. J Cardiovasc Dev Dis. 2024;11. doi:10.3390/jcdd11040126
- Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. doi:10.1016/j.jacc.2024.02.016
- Liakos CI, Lanaras L, Bristianou M, Papadopoulos DP. Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals. Lipids. 2024;59:67. doi:10.1002/lipd.12391
- Ganuza E, Etomi EH, Olson M, Whisner CM. Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population. Front Nutr. 2024;11:1293909. doi:10.3389/fnut.2024.1293909
- Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. doi:10.3390/medicina60010075
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